December 10, 2008

This week's journal club presentation will be given by Robert Axtell (Steinman lab). We will be in CCSR 4205 (12:30 - 1:30pm) Wed. Dec. 10th. This will be the final journal club presentation this year - journal club will resume on January 7th 2009.

Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway.
Cao W, Manicassamy S, Tang H, Kasturi SP, Pirani A, Murthy N, Pulendran B.
Nat Immunol. 2008 Oct;9(10):1157-64.

Link to paper.

And the corresponding News & Views:
RAPping production of type I interferon in pDCs through mTOR.
Costa-Mattioli M, Sonenberg N.
Nat Immunol. 2008 Oct;9(10):1097-9.

Link to paper.