Call for presenters (Winter 2008)

Greetings Stanford Immunologists,

Ah the holidays, time to give thanks and gifts to one another, reflect upon the year, and ... volunteer to present at next quarter's journal club!

As usual our journal club will meet on Wednesdays, from Noon-1pm.

For this Winter quarter we have the following dates:
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- Jan 16
- Jan 23
- Jan 30
- Feb 6
- Feb 13
- Feb 20 (presenter - tentative)
- Feb 27 (presenter - confirmed)
- Mar 5 (presenter - confirmed)
- Mar 12 (presenter - confirmed)
- Mar 19 (presenter - tentative)
- Mar 26 (presenter - confirmed)


Please let me know if you would like to present at one of the still available dates.

Happy holidays and see you in the new year,
Jack

Dec. 12th (Wed)

On Wednesday, Dec. 12th, starting at Noon in CCSR 4205, Emilie V. (Fathman Lab) will present:

DUBA: A Deubiquitinase That Regulates Type I Interferon Production

Nobuhiko Kayagaki, Qui Phung, Salina Chan, Ruchir Chaudhari, Casey Quan, Karen M. O'Rourke, Michael Eby, Eric Pietras, Genhong Cheng, J. Fernando Bazan, Zemin Zhang, David Arnott, Vishva M. Dixit

Science, 7 December 2007: Vol. 318. no. 5856, pp. 1628 - 1632.

Link to article: click here

Dec. 5th (Wed)

On Wednesday, Dec. 5th, starting at Noon in CCSR 4205, Michael B. (Contag Lab) will present:

WORLD AIDS DAY (12/1): ANNUAL UPDATE

From Michael:

There are no papers to read. Just come, relax over lunch and hear a summary of what epidemiologists, virologists and immunologists have been finding in the past year.

Nov. 28th (Wed)

On Wednesday, Nov. 28th, starting at Noon in CCSR 4205, Remi C. (Fathman Lab) will present:

Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

Roberto Lande, Josh Gregorio, Valeria Facchinetti, Bithi Chatterjee, Yi-Hong Wang, Bernhard Homey, Wei Cao, Yui-Hsi Wang, Bing Su, Frank O. Nestle, Tomasz Zal, Ira Mellman, Jens-Michael Schröder, Yong-Jun Liu & Michel Gilliet

Nature 449, 564-569.

Link to article: click here

News and views pertaining to this article: click here

Nov. 14th (Wed)

On Wednesday, Nov. 14th, starting at Noon in CCSR 4205, Shannon D. (Steinman Lab) will present:

Stimulation of the Intracellular Bacterial Sensor NOD2 Programs Dendritic Cells to Promote Interleukin-17 Production in Human Memory T Cells

Astrid J. van Beelen, Zuzana Zelinkova, Esther W. Taanman-Kueter, Femke J. Muller, Daniel W. Hommes, Sebastian A.J. Zaat, Martien L. Kapsenberg, and Esther C. de Jong

Immunity. Volume 27, Issue 4, 26 October 2007, Pages 660-669

Link to article: click here

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Shannon's teaser:

This paper by van Beelen and colleagues describes how bacteria can drive the generation human Th17 cells. The authors show that microbial products bind to and work via TLRs and NOD2 in dendritic cells to induce expression of IL-1 and IL-23, which are requisite for IL-17 production by human CD4+ T cells.

Oct. 31st (Wed)

On Wednesday, Oct. 31st, starting at Noon in CCSR 4205, Emily S. (Robinson Lab) will present:

Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system

Wendy S. Garrett, Graham M. Lord, Shivesh Punit, Geanncarlo Lugo-Villarino, Sarkis K. Mazmanian, Susumu Ito, Jonathan N. Glickman, and Laurie H. Glimcher

Cell, Vol 131, 33-45, 05 October 2007

Link to article: click here

Oct. 24th (Wed)

On Wednesday, Oct. 24th, starting at Noon in CCSR 4205, Tin M. (Chen Lab) will present:

Regulation of the germinal center response by microRNA-155

Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K.

Science. 2007 Apr 27;316(5824):604-8.

Link to article: click here

and

Requirement of bic/microRNA-155 for normal immune function

Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, van Dongen S, Grocock RJ, Das PP, Miska EA, Vetrie D, Okkenhaug K, Enright AJ, Dougan G, Turner M, Bradley A.

Science. 2007 Apr 27;316(5824):608-11.

Link to article: click here

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Tin's teaser:

MicroRNAs represent a fundamental layer of gene regulation that mediate posttranscriptional gene repression by binding to complementary mRNA transcripts of target genes. While small in stature, their impressions can be felt across various biological processes as computational prediction suggests that at least one-third of all protein-coding genes are regulated by miRNAs. Their role on the immune system was recently appreciated as two independent groups knocked out the gene that encodes for microRNA-155. T cells, B cells, and dendritic cells were all found to function improperly in these mutant mice and contributed to their immunodeficiency. Mir-155-deficient mice were unable to generate normal germinal center reactions, thereby impairing T cell-dependent antibody responses. These mutant mice also displayed significant lung airway remodeling that was consistent asthma pathology. Moreover, when vaccinated with an attenuated form of Samonella, the animals failed to develop protective immunity with the majority of mice succumbing to the virulent strain within a month. These observations suggest that miR-155 plays an important role in the homeostasis and function of the immune system. These studies also underscores the broad impact one particular microRNA can have by controlling multiple genes.

Oct. 17th (Wed)

On Wednesday, Oct. 17th, starting at Noon in CCSR 4205, Ana da S. (Fathman Lab) will present:

Dynamic imaging of chemokine-dependent CD8+ T cell help for CD8+ T cell responses

Stéphanie Hugues, Alix Scholer, Alexandre Boissonnas, Alexander Nussbaum, Christophe Combadière, Sebastian Amigorena & Luc Fetle

Nature Immunology 8, 921 - 930 (2007)

Link to article: click here

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Ana's teaser:

Interaction between cells during an immune response is one of the mechanisms that often increases the efficiency in eliminating target antigens. It is well established that CD4+ T cells are the major “helper” cell for B and CD8 T cell activation, by releasing cytokines that directly activate these cells or by increasing the ability of APCs to professionally activate other CD4+ or CD8+ T cells (ex. increasing the expression of co-stimulators molecules). Similar to CD4+ T cells, NK cells and NK T cells seem to influence the maturation of DCs and “help” CD4+ and CD8+ T cell responses in vitro and in vivo. We have been mainly focused on enhancing the immune response to a specific antigen by increasing function of the “helper” cells specific to the same antigen and underscoring the effect of bystanders cells that somehow are also activated in these microenvironments. Here Hugues et al. beautifully show during the initiation of antigen-specific CD8+ T cells that naïve polyclonal CD8+ T cells also interact with the mature dendritic cells and as a result a strong CD8+ T cell antigen-specific response is elaborated. The interaction between DCs and poly-T cells seem to be dependent on CCR5 chemokine. Then, the strong CD8+ T cell response induced by mature DCs against a first peptide favored the induction of a second antigen-specific CD8+ T cell strong enough to mediate rejection of an established B16 tumor.

Oct. 10th (Wed)

On Wednesday, Oct. 10th, starting at Noon in CCSR 4205, Candace C. (McDevitt and Utz Labs) will present:

Mammalian N-Glycan Branching Protects against Innate Immune Self-Recognition and Inflammation in Autoimmune Disease Pathogenesis

Ryan S. Green, Erica L. Stone, Mari Tenno, Eero Lehtonen, Marilyn G. Farquhar and Jamey D. Marth

Immunity, Volume 27, Issue 2, Pages 308-320

Link to article: click here

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Candace's teaser:

Glycosylation plays a critical role in the regulation of numerous cellular processes, including cell adhesion, cell activation, and protein trafficking. One of the enzymes responsible for a specific glycan is alpha-mannosidase II. Interestingly, when this gene is knocked out in mice, they develop an autoimmune disease similar to lupus! In addition, the manifestation of disease is not dependent on adaptive immunity. These findings underscore the significance of sugar moieties as antigens. It also suggests that altered sugars can act as pathogen-associated molecular patterns (PAMPs) and trigger an immune response.

Oct. 3rd (Wed)

On Wednesday, Oct. 3rd, starting at Noon in CCSR 4205, Byron E. (Nolan Lab) will present:

"A Statistician Visits the Flow Lab"

Description:

Statisticians are just now really discovering flow cytometry,
particularly phospho-flow cytometry, as a rich source of high
throughput data. In this talk, I will discuss the problem of analyzing
flow data, in the context of some experiments being done in the Nolan
lab, from a statistician's point-of-view, some pointers to the current
state-of-the-art (published and not), and a glimpse at the tools some
of us have been building to help bring more collaborators and
analytical options to the table.

Sept. 26th (Wed) - Special Presentation

On Wednesday, Sept. 26th, starting at Noon in CCSR 4205, special guest Kimberly S. (Lane Library) will present:

Lane Library's Resources for Immunology

Topics include:

• Identifying Clincal Trials (basic scientists looking for clinical applications of their work)
• Who's Citing my work- LANL browse, add'l databases
• IMAGES - ImagesMD, AccessMed overview, Thieme
• online books core searches
• (and more...)

I know for me there were quite a number of resources that I had not been aware of that she brought to light. As we start this year's journal club and come back from the Summer days I hope you will join us and perhaps gain a better understanding of what research tools are available to help jump-start things. There will also be time to ask Kim any other questions you may have.

Lane Library

Call for presenters (Fall 2007)

Greetings Stanford Immunologists,

I hope everyone has enjoyed a great Summer and is well rested and ready for Fall.

First, for those who missed the last meeting before Summer, a reiteration of thanks to Remi Creusot is in order for his 3+ years of organization and service to the journal club. Thanks Remi!

As usual the journal club will meet on Wednesdays, from Noon-1pm.

For this Fall quarter we still have the following dates available for presenters:
----------

- Sept. 26
- Oct. 10
- Oct. 17
- Nov. 14
- Nov. 28
- Dec. 5
- Dec. 12


Please let me know if you would like to present at one of these dates.

Thanks and see you soon,
Jack

First post!

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Great, how about trying to link to articles?

A link to an abstract: click here

A link to a full article: click here