On Wednesday, Oct. 10th, starting at Noon in CCSR 4205, Candace C. (McDevitt and Utz Labs) will present:
Mammalian N-Glycan Branching Protects against Innate Immune Self-Recognition and Inflammation in Autoimmune Disease Pathogenesis
Ryan S. Green, Erica L. Stone, Mari Tenno, Eero Lehtonen, Marilyn G. Farquhar and Jamey D. Marth
Immunity, Volume 27, Issue 2, Pages 308-320
Link to article: click here
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Candace's teaser:
Glycosylation plays a critical role in the regulation of numerous cellular processes, including cell adhesion, cell activation, and protein trafficking. One of the enzymes responsible for a specific glycan is alpha-mannosidase II. Interestingly, when this gene is knocked out in mice, they develop an autoimmune disease similar to lupus! In addition, the manifestation of disease is not dependent on adaptive immunity. These findings underscore the significance of sugar moieties as antigens. It also suggests that altered sugars can act as pathogen-associated molecular patterns (PAMPs) and trigger an immune response.
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