Tuesday, December 9, 2008

December 10, 2008

This week's journal club presentation will be given by Robert Axtell (Steinman lab). We will be in CCSR 4205 (12:30 - 1:30pm) Wed. Dec. 10th. This will be the final journal club presentation this year - journal club will resume on January 7th 2009.

Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway.
Cao W, Manicassamy S, Tang H, Kasturi SP, Pirani A, Murthy N, Pulendran B.
Nat Immunol. 2008 Oct;9(10):1157-64.
Link to paper.

And the corresponding News & Views:
RAPping production of type I interferon in pDCs through mTOR.
Costa-Mattioli M, Sonenberg N.
Nat Immunol. 2008 Oct;9(10):1097-9.

Wednesday, December 3, 2008

December 3, 2008

This week's journal club presentation will be given by Shannon Dunn (Steinman lab). We will be in CCSR 4205 (12:30 - 1:30pm). Shannon will be discussing two back to back papers published in Nature Immunology that describe a new IL-9 producing T helper subset.

Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.
Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A, Buer J, Martin B, Wilhelm C, Stockinger B.
Nat Immunol. 2008 Dec;9(12):1341-6.
Link to paper

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.
Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, Mitsdoerffer M, Strom TB, Elyaman W, Ho IC, Khoury S, Oukka M, Kuchroo VK.
Nat Immunol. 2008 Dec;9(12):1347-55.

November 12, 2008

This week's presentation will be given by Lee Herzenberg. Lee will be discussing "Unpopular Ideas in Science".

Please note, we are back in the normal room (CCSR 4205, 12:30 - 1:30pm).

November 5, 2008

This week's journal club presentation will be given by Archana Iyer (Galli lab). Please note the room change: we will be in MSOB X303 (12:30 - 1:30pm). The paper selected is:

CTLA-4 Control over Foxp3+ Regulatory T cell Function.

Kajsa Wing, Yasushi Onishi, Paz Prieto-Martin, Tomoyuki Yamaguchi, Makoto Miyara, Zoltan Fehevari, Takashi Nomura, & Shimon Sakaguchi

Science. 2008 Oct; 322: 271-275.

October 29, 2008

This week's journal club presentation will be given by Remi Creusot (Fathman Lab). Please note the room change: we will be in MSOB X303 (12:30 - 1:30pm). 

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance.

Nedjic J, Aichinger M, Emmerich J, Mizushima N, Klein L.

Nature. 2008 Sep 18;455(7211):396-400.

October 22, 2008

This week's journal club presentation will be given by Jun Seita (Weissman Lab). We will be in CCSR 4205 (12:30 - 1:30pm).

Jun's talk is titled:

"Quantitative Analysis of Microarray Data based on Dynamic-range Database"

October 15, 2008

This week's journal club presentation will be given by Jason Ptacek (Nolan lab). We will be in CCSR 4205 (12:30 - 1:30pm).

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis.

Neubert K, Meister S, Moser K, Weisel F, Maseda D, Amann K, Wiethe C, Winkler TH, Kalden JR, Manz RA, Voll RE.

Nat Med. 2008 Jul;14(7):748-55.

October 8, 2008

This week's journal club presentation will be given by Janet Kalesnikoff. Please note the new room (CCSR 4205) and time (12:30 - 1:30pm).

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense.

Shida Yousefi, Jeffrey A Gold, Nicola Andina, James J Lee, Ann M Kelly, Evelyne Kozlowski, Inès Schmid, Alex Straumann, Janine Reichenbach, Gerald J Gleich & Hans-Uwe Simon

Nat Med. 2008 Sept;14(9):949-53.

Link to article: click here

September 24, 2008

Yannick Pouliot, Ph.D., MBA from Lane Library will be giving a talk entitled "3 things you do not want to do without."

Tuesday, June 24, 2008

Off until Fall

Thank you for your participation in the successful 2007-2008 Postdoctoral Immunology Journal Club!

We will resume again in the Fall for the 2008-2009 academic calendar.

Have a great Summer,
Jack


Tuesday, June 17, 2008

June 18th (Wed.)

On Wednesday, June 18th, starting at Noon in CCSR 4105, Mark D. will present:

"Navigating Contemporary Immunology"

Two selected readings (downloads as Adobe .pdf files):

How to ask questions

Hegemony of Mediocrity



Tuesday, June 10, 2008

June 11th (Wed.)

On Wednesday, June 11th, starting at Noon in CCSR 4105, Gerald C. will present:

"How to Read a Scientific Paper"

(With selected illustrative sample papers.)




Crabtree Lab


Tuesday, June 3, 2008

June 4th (Wed.)

On Wednesday, June 4th, starting at Noon in CCSR 4105, Shigeru O. will present:

Using Engineered Scaffold Interactions to Reshape MAP Kinase Pathway Signaling Dynamics.

Caleb J. Bashor, Noah C. Helman, Shude Yan, Wendell A. Lim.

Science 14 March 2008: Vol. 319. no. 5869, pp. 1539 - 1543.

Link to article: click here

Tuesday, May 27, 2008

May 28th (Wed.)

On Wednesday, May 28th, starting at Noon in CCSR 4105, Evan N. will present:

Vaccine adjuvants alter TCR-based selection thresholds.

Malherbe L, Mark L, Fazilleau N, McHeyzer-Williams LJ, McHeyzer-Williams MG.

Immunity. 2008 May;28(5):698-709.

Link to article: click here

Tuesday, May 20, 2008

May 21st (Wed.)

On Wednesday, May 21st, starting at Noon in CCSR 4105, Dennis L. will present:

Noninvasive in vivo imaging of pancreatic islet cell biology.

Stephan Speier, Daniel Nyqvist, Over Cabrera, Jia Yu, R Damaris Molano, Antonello Pileggi, Tilo Moede, Martin Köhler, Johannes Wilbertz, Barbara Leibiger, Camillo Ricordi, Ingo B Leibiger, Alejandro Caicedo & Per-Olof Berggren

Nat Med. 2008 May;14(5):574-8.

Link to article: click here

Tuesday, May 13, 2008

May 14th (Wed.)

On Wednesday, May 14th, starting at Noon in CCSR 4105, Ana S. will present:

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection.

Silvia Piconese, Barbara Valzasina, and Mario P. Colombo

The Journal of Experimental Medicine, Vol. 205, No. 4, 825-839.

Link to article: click here

Monday, May 5, 2008

May 7th (Wed.)

On Wednesday, May 7th, starting at Noon in CCSR 4105, Linh N. will present:

Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor.

Francisco J. Quintana, Alexandre S. Basso, Antonio H. Iglesias, Thomas Korn, Mauricio F. Farez, Estelle Bettelli, Mario Caccamo, Mohamed Oukka & Howard L. Weiner

Nature. 2008 May 1;453(7191):65-71.

Link to article: click here


Monday, April 28, 2008

Apr. 30th (Wed.)

On Wednesday, Apr. 30th, starting at Noon in CCSR 4105, Emanuela S. will present:

Purging metastases in lymphoid organs using a combination of antigen-nonspecific adoptive T cell therapy, oncolytic virotherapy and immunotherapy.

Qiao J, Kottke T, Willmon C, Galivo F, Wongthida P, Diaz RM, Thompson J, Ryno P, Barber GN, Chester J, Selby P, Harrington K, Melcher A, Vile RG.

Nat Med. 2008 Jan;14(1):37-44.

Link to article: click here

Monday, April 21, 2008

Apr. 23rd (Wed.)

On Wednesday, Apr. 23rd, starting at Noon in CCSR 4105, Cornelia E. will present:

Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional DC progenitors in mouse bone marrow

Nobuyuki Onai, Aya Obata-Onai, Michael A Schmid, Toshiaki Ohteki, David Jarrossay & Markus G Manz

Nature Immunology Nov 2007 v8 n11 p1207

Link to article: click here


Monday, April 14, 2008

Apr. 16th (Wed.)

On Wednesday, Apr. 16th, starting at Noon in CCSR 4105, Will T. will present:

Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice.

Liu C, Lou Y, Lizée G, Qin H, Liu S, Rabinovich B, Kim GJ, Wang YH, Ye Y, Sikora AG, Overwijk WW, Liu YJ, Wang G, Hwu P.

J Clin Invest. 2008 Mar;118(3):1165-75.

Link to article: click here

Tuesday, April 8, 2008

Apr. 9th (Wed.)

On Wednesday, Apr. 9th, starting at Noon in CCSR 4105, Tim D. (faculty) will present:

Stanford Small Animal Imaging Facility Core

Information can be found here:

http://sci3.stanford.edu/


http://mips.stanford.edu/

Wednesday, March 26, 2008

Call for presenters (Spring 2008)

====
Updated: April 1, 2008
====

Greetings Stanford Immunologists,

We're looking for volunteers to present for the upcoming Spring 2008 Postdoctoral Immunology Journal Club, continuing the wonderful slate of presentations we've all come to enjoy.

As usual our journal club will meet on Wednesdays, from Noon-1pm.

For this quarter we have the following dates:
----------
  • Apr. 9 (open)
  • ***Apr. 16 (tentative)
  • ***Apr. 23 (tentative)
  • Apr. 30 (open)
  • May 7 (open)
  • ***May 14 (filled)
  • ***May 21 (filled)
  • May 28 (open)
  • Jun. 4 (open)
  • Jun. 11 (open)
  • Jun. 18 (open)
  • Jun. 25 (open)

Please let me know if you would like to present at one of these dates.

Thanks,
Jack

Monday, March 24, 2008

Mar. 26th (Wed.)

On Wednesday, Mar. 26th, starting at Noon in CCSR 4105, Sara M. (faculty) will present:

A novel M cell–specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses

Tomonori Nochi, Yoshikazu Yuki, Akiko Matsumura, Mio Mejima, Kazutaka Terahara, Dong-Young Kim, Satoshi Fukuyama, Kiyoko Iwatsuki-Horimoto, Yoshihiro Kawaoka, Tomoko Kohda, Shunji Kozaki, Osamu Igarashi, and Hiroshi Kiyono

J. Exp. Med. 2007 204: 2789-2796.


Link to article: click here

Monday, March 17, 2008

Mar. 19th (Wed.)

On Wednesday, Mar. 19th, starting at Noon in CCSR 4105, Rong L. will present:

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

Adam G. W. Matthews, Alex J. Kuo, Santiago Ramón-Maiques, Sunmi Han, Karen S. Champagne, Dmitri Ivanov, Mercedes Gallardo, Dylan Carney, Peggie Cheung, David N. Ciccone, Kay L. Walter, Paul J. Utz, Yang Shi, Tatiana G. Kutateladze, Wei Yang, Or Gozani & Marjorie A. Oettinger

Nature 450, 1106-1110 (13 December 2007)


Link to article: click here

Monday, March 10, 2008

Mar. 12th (Wed.)

On Wednesday, Mar. 12th, starting at Noon in CCSR 4105, Aleksey Y. (Felsher Lab) will present:

NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins

Guo N. Huang, David L. Huso, Samuel Bouyain, Jianchen Tu, Kelly A. McCorkell, Michael J. May, Yuwen Zhu, Michael Lutz, Samuel Collins, Marlin Dehoff, Shin Kang, Katharine Whartenby, Jonathan Powell, Daniel Leahy, and Paul F. Worley

Science 25 January 2008: Vol. 319. no. 5862, pp. 476 - 481


Link to article: click here

Tuesday, March 4, 2008

Mar. 5th (Wed.)

On Wednesday, Mar. 5th, starting at Noon in CCSR 4105, Jason P. (Nolan Lab) will present:

CD4+CD25+Foxp3+ regulatory T cells induce cytokine
deprivation–mediated apoptosis of effector CD4+ T cells


Pushpa Pandiyan, Lixin Zheng, Satoru Ishihara, Jennifer Reed & Michael J Lenardo.

Nature Immunology 8, 1353 - 1362 (2007).


Link to article: click here

Monday, February 25, 2008

Feb. 27th (Wed.)

On Wednesday, Feb. 27th, starting at Noon in CCSR 4105, Roopa B. (Steinman Lab) will present:

Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

Ingunn M Stromnes, Lauren M Cerretti, Denny Liggitt, Robert A Harris & Joan M Goverman.

Published online: 17 February 2008; | doi:10.1038/nm1715


Link to article: click here

Tuesday, February 19, 2008

Feb. 20th (Wed.)

On Wednesday, Feb. 20th, starting at Noon in CCSR 4105, Tin M. (Chen Lab) will present:

Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice

Hsu HC, Yang P, Wang J, Wu Q, Myers R, Chen J, Yi J, Guentert T, Tousson A, Stanus AL, Le TV, Lorenz RG, Xu H, Kolls JK, Carter RH, Chaplin DD, Williams RW, Mountz JD.

Nat Immunol. 2008 Feb;9(2):166-75.


Link to article: click here

Monday, February 11, 2008

Feb. 13th (Wed.)

On Wednesday, Feb. 13th, starting at Noon in CCSR 4105, Crystal B. (Lewis Lab) will present:

Novel cell death program leads to neutrophil extracellular traps

Tobias A. Fuchs, Ulrike Abed, Christian Goosmann, Robert Hurwitz, Ilka Schulze, Volker Wahn, Yvette Weinrauch, Volker Brinkmann, and Arturo Zychlinsky

J. Cell Biol. 2007 176: 231-241.

Link to article: click here

Also, Crystal has included a review article relevant to the research article: click here

***
From Crystal:

Attached is the journal club article that I picked for next week (Fuchs et al., 2007). The article is about neutrophils and their ability to make NETs (Neutrophil Extracellular Traps). The paper has some every nice time-lapse microscopy experiments of the neutrophils making the NETs and shows that NETs depend on the generation of reactive oxygen species (ROS) by NADPH oxidase. The second article (Brinkmann and Zychlinsky) is a recent review article which gives an overview of what is known about NETs and discusses their diverse roles in infection including cystic fibrosis and systemic lupus erythematosis.

Monday, February 4, 2008

Feb. 6th (Wed.)

On Wednesday, Feb. 6th, starting at Noon in CCSR 4105, Chih L. (Utz/Gozani Labs) will present:

Developmental switch of intestinal antimicrobial peptide expression

Sandrine Ménard, Valentina Förster, Michael Lotz, Dominique Gütle, Claudia U. Duerr, Richard L. Gallo, Birgitta Henriques-Normark, Katrin Pütsep, Mats Andersson, Erik O. Glocker, and Mathias W. Hornef

The Journal of Experimental Medicine, Vol. 205, No. 1, 183-193.

Link to article: click here

Tuesday, January 29, 2008

Jan. 30th (Wed.)

On Wednesday, Jan. 30th, starting at Noon in CCSR 4105, Marcy V. (Brown Lab) will present:

Immunosurveillance by Hematopoietic Progenitor Cells Trafficking through Blood, Lymph, and Peripheral Tissues

Steffen Massberg, Patrick Schaerli, Irina Knezevic-Maramica, Maria Köllnberger, Noah Tubo, E. Ashley Moseman, Ines V. Huff, Tobias Junt, Amy J. Wagers, Irina B. Mazo, and Ulrich H. von Andrian

Cell, Vol 131, 994-1008, 30 November 2007.

Link to article: click here

Monday, January 21, 2008

Jan. 23rd (Wed.)

*** Note: CCSR 4105 (green side building) ***

On Wednesday, Jan.23rd, starting at Noon in CCSR 4105, Bindu V. (Levy Lab) will present:

Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling

Chrystal M. Paulos, Claudia Wrzesinski, Andrew Kaiser,, Christian S. Hinrichs, Marcello Chieppa, Lydie Cassard, Douglas C. Palmer, Andrea Boni, Pawel Muranski, Zhiya Yu, Luca Gattinoni, Paul A. Antony, Steven A. Rosenberg, Nicholas P. Restifo

J. Clin. Invest. 117: 2197-2204 (2007).

Link to article: click here

Monday, January 14, 2008

Jan. 16th (Wed)

*** Note: CCSR 4105 (green side building) ***

On Wednesday, Jan. 16th, starting at Noon in CCSR 4105, Martin M. (Visiting Scholar) will present:

Chronic Lymphocytic Leukaemia: Clinical Translations from Biological Features


T.J Hamblin

(2005) 294: 165-185. Current Topics in Microbiology and Immunology.
“Chronic Lymphocytic Leukemia", edited by F. Caligaris-Cappio and R. Dalla-Favera.

Uploaded article (pdf): click here

Monday, January 7, 2008

Immunology Journal Club, Jan. 16th (CCSR 4105)

Hello Stanford Immunologists,

Welcome back to another installment of the journal club. Our first session will be Jan. 16th from Noon-1pm.

Please note that this quarter we have CCSR 4105 (green side, in the other CCSR building from last quarter).

For those who have signed up to present: thank you, please visit the blog and check on the right-side column that everything appears correct.

http://immunobeat.blogspot.com

Thanks again to Maureen Panganiban for helping to make things run smoothly!

See you soon,
Jack