December 10, 2008

This week's journal club presentation will be given by Robert Axtell (Steinman lab). We will be in CCSR 4205 (12:30 - 1:30pm) Wed. Dec. 10th. This will be the final journal club presentation this year - journal club will resume on January 7th 2009.

Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway.
Cao W, Manicassamy S, Tang H, Kasturi SP, Pirani A, Murthy N, Pulendran B.
Nat Immunol. 2008 Oct;9(10):1157-64.

Link to paper.

And the corresponding News & Views:
RAPping production of type I interferon in pDCs through mTOR.
Costa-Mattioli M, Sonenberg N.
Nat Immunol. 2008 Oct;9(10):1097-9.

Link to paper.

December 3, 2008

This week's journal club presentation will be given by Shannon Dunn (Steinman lab). We will be in CCSR 4205 (12:30 - 1:30pm). Shannon will be discussing two back to back papers published in Nature Immunology that describe a new IL-9 producing T helper subset.

Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.
Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A, Buer J, Martin B, Wilhelm C, Stockinger B.
Nat Immunol. 2008 Dec;9(12):1341-6.
Link to paper

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.
Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, Mitsdoerffer M, Strom TB, Elyaman W, Ho IC, Khoury S, Oukka M, Kuchroo VK.
Nat Immunol. 2008 Dec;9(12):1347-55.

Link to paper

November 12, 2008

This week's presentation will be given by Lee Herzenberg. Lee will be discussing "Unpopular Ideas in Science".

Please note, we are back in the normal room (CCSR 4205, 12:30 - 1:30pm).

November 5, 2008

This week's journal club presentation will be given by Archana Iyer (Galli lab). Please note the room change: we will be in MSOB X303 (12:30 - 1:30pm). The paper selected is:

CTLA-4 Control over Foxp3+ Regulatory T cell Function.

Kajsa Wing, Yasushi Onishi, Paz Prieto-Martin, Tomoyuki Yamaguchi, Makoto Miyara, Zoltan Fehevari, Takashi Nomura, & Shimon Sakaguchi

Science. 2008 Oct; 322: 271-275.

Link to paper

October 29, 2008

This week's journal club presentation will be given by Remi Creusot (Fathman Lab). Please note the room change: we will be in MSOB X303 (12:30 - 1:30pm). 

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance.

Nedjic J, Aichinger M, Emmerich J, Mizushima N, Klein L.

Nature. 2008 Sep 18;455(7211):396-400.

Link to paper

October 22, 2008

This week's journal club presentation will be given by Jun Seita (Weissman Lab). We will be in CCSR 4205 (12:30 - 1:30pm).

Jun's talk is titled:

"Quantitative Analysis of Microarray Data based on Dynamic-range Database"

October 15, 2008

This week's journal club presentation will be given by Jason Ptacek (Nolan lab). We will be in CCSR 4205 (12:30 - 1:30pm).

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis.

Neubert K, Meister S, Moser K, Weisel F, Maseda D, Amann K, Wiethe C, Winkler TH, Kalden JR, Manz RA, Voll RE.

Nat Med. 2008 Jul;14(7):748-55.

Link to paper

October 8, 2008

This week's journal club presentation will be given by Janet Kalesnikoff. Please note the new room (CCSR 4205) and time (12:30 - 1:30pm).

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense.

Shida Yousefi, Jeffrey A Gold, Nicola Andina, James J Lee, Ann M Kelly, Evelyne Kozlowski, Inès Schmid, Alex Straumann, Janine Reichenbach, Gerald J Gleich & Hans-Uwe Simon

Nat Med. 2008 Sept;14(9):949-53.

Link to article: click here

September 24, 2008

Yannick Pouliot, Ph.D., MBA from Lane Library will be giving a talk entitled "3 things you do not want to do without."