On Wednesday, Nov. 14th, starting at Noon in CCSR 4205, Shannon D. (Steinman Lab) will present:
Stimulation of the Intracellular Bacterial Sensor NOD2 Programs Dendritic Cells to Promote Interleukin-17 Production in Human Memory T Cells
Astrid J. van Beelen, Zuzana Zelinkova, Esther W. Taanman-Kueter, Femke J. Muller, Daniel W. Hommes, Sebastian A.J. Zaat, Martien L. Kapsenberg, and Esther C. de Jong
Immunity. Volume 27, Issue 4, 26 October 2007, Pages 660-669
Link to article: click here
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Shannon's teaser:
This paper by van Beelen and colleagues describes how bacteria can drive the generation human Th17 cells. The authors show that microbial products bind to and work via TLRs and NOD2 in dendritic cells to induce expression of IL-1 and IL-23, which are requisite for IL-17 production by human CD4+ T cells.
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