This week's journal club presentation will be given by Shannon Dunn (Steinman lab). We will be in CCSR 4205 (12:30 - 1:30pm). Shannon will be discussing two back to back papers published in Nature Immunology that describe a new IL-9 producing T helper subset.
Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.
Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A, Buer J, Martin B, Wilhelm C, Stockinger B.
Nat Immunol. 2008 Dec;9(12):1341-6.
Link to paper
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.
Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, Mitsdoerffer M, Strom TB, Elyaman W, Ho IC, Khoury S, Oukka M, Kuchroo VK.
Nat Immunol. 2008 Dec;9(12):1347-55.
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