Nov. 28th (Wed)

On Wednesday, Nov. 28th, starting at Noon in CCSR 4205, Remi C. (Fathman Lab) will present:

Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

Roberto Lande, Josh Gregorio, Valeria Facchinetti, Bithi Chatterjee, Yi-Hong Wang, Bernhard Homey, Wei Cao, Yui-Hsi Wang, Bing Su, Frank O. Nestle, Tomasz Zal, Ira Mellman, Jens-Michael Schröder, Yong-Jun Liu & Michel Gilliet

Nature 449, 564-569.

Link to article: click here

News and views pertaining to this article: click here

Nov. 14th (Wed)

On Wednesday, Nov. 14th, starting at Noon in CCSR 4205, Shannon D. (Steinman Lab) will present:

Stimulation of the Intracellular Bacterial Sensor NOD2 Programs Dendritic Cells to Promote Interleukin-17 Production in Human Memory T Cells

Astrid J. van Beelen, Zuzana Zelinkova, Esther W. Taanman-Kueter, Femke J. Muller, Daniel W. Hommes, Sebastian A.J. Zaat, Martien L. Kapsenberg, and Esther C. de Jong

Immunity. Volume 27, Issue 4, 26 October 2007, Pages 660-669

Link to article: click here

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Shannon's teaser:

This paper by van Beelen and colleagues describes how bacteria can drive the generation human Th17 cells. The authors show that microbial products bind to and work via TLRs and NOD2 in dendritic cells to induce expression of IL-1 and IL-23, which are requisite for IL-17 production by human CD4+ T cells.